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Most Cited (> 50 citations) Publications (Hirsch's citation h-index = 81):
1. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F. (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13:795-808 (cited 1,460 times). 2. Gorczyca W, Gong J, Darzynkiewicz. (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53:1945-1951 (cited 802 times). 3. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami, M. Traganos F. (1997) Cytometry in cell necrobiology. Analysis of apoptosis and accidental cell death (necrosis). Cytometry 27:1-20 (cited 640 times). 4. Gong JP, Traganos F, Darzynkiewicz Z. (1994) A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 218:314-319 (cited 450 times). 5. Darzynkiewicz Z, Traganos F, Sharpless T, Melamed MR. (1976) Lymphocyte stimulation: A rapid multiparameter analysis. Proc Natl Acad Sci USA 73:2881-2884 (cited 442 times) 6. Traganos F, Darzynkiewicz Z, Sharpless T, Melamed MR. (1977) Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J Histochem Cytochem 25:46-56 (cited 422 times). 7. Gorczyca W, Gong JP, Ardelt B, Traganos F, Darzynkiewicz Z. (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 53:3186-3192 (cited 401 times). 8. Evenson DP, Darzynkiewicz Z, Melamed MR. (1980) Relation of mammalian sperm chromatin heterogeneity to fertility. Science 210:1131-1133, 1980 (cited 352 times). 9. Darzynkiewicz Z, Traganos F, Melamed MR.(1980) New cell cycle compartments identified by multiparameter flow cytometry. Cytometry 1:98-108 (cited 292 times). 10. Gorczyca W, Bigman K, Mittelman A, Ahmed T, Gong J, Melamed MR, Darzynkiewicz Z. (1993) Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia (Baltimore) 7: 659-670 (cited 260 times). 11. Andreeff M, Darzynkiewicz Z, Sharpless TK, Clarkson BD, Melamed MR. (1980) Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55:282-293 (cited 247 times). 12. Darzynkiewicz Z, Sharpless T, Staiano-Coico L, Melamed MR. (1980) Subcompartments of the G1 phase of cell cycle detected by flow cytometry. Proc Natl Acad Sci USA 77:6696-6700 (cited 243 times). 13. Bories D, Raynal M-C, Solomon DH, Darzynkiewicz Z, Cayre YE. (1989) Down-regulation of a serine protease, Myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell 59: 959-968 (cited 242 times). 14. Garcia-Valenzuela E, Gorczyca W, Darzynkiewicz Z, Sharma SC. (1994) Apoptosis in adult retinal ganglion cells after axotomy. J Neurobiol 25: 431-438 (cited 242 times). 15. Darzynkiewicz Z. (1994) Assays of cell viability. Discrimination of cells dying by apoptosis. Meth Cell Biol 41: 15-38 (cited 240 times). 16. Gorczyca W, Bruno S, Darzynkiewicz RJ, Gong JP, Darzynkiewicz Z. (1992) DNA strand breaks occurring during apoptosis: Their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1:639-648 (cited 230 times). 17. Jakóbisiak M, Bruno S, Skierski J, Darzynkiewicz Z. (1991) The cell cycle specific effects of lovastatin. Proc Natl Acad Sci USA 88:3628-3632 (cited 225 times). 18. Darzynkiewicz Z, Williamson B, Carswell EA, Old LJ. (1984) The cell cycle specific effects of tumor necrosis factor. Cancer Res 44:83-90 (cited 215 times). 19. Darzynkiewicz Z, Traganos F, Kapuscinski J, Staiano-Coico L, Melamed MR. (1984) Accessibility of DNA in situ to various fluorochromes: Relationship to chromatin changes during erythroid differentiation of Friend leukemia cells. Cytometry 5:355-363 (cited 207 times). 20. Gorczyca W, Traganos F, Jesionowska H, Darzynkiewicz Z. (1993) Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells. Analogy to apoptosis of somatic cells. Exp Cell Res 207:202-205 (cited 202 times). 21. Darzynkiewicz Z, Traganos F, Sharpless TK, Melamed MR. (1975) Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp Cell Res 95:143-153 (cited 196 times). 22. Olszewski W, Darzynkiewicz Z, Rosen P, Schwartz MK, Melamed MR. (1981) Flow cytometry of breast carcinoma. I. Relation of DNA ploidy level to histology and estrogen receptors. Cancer 48:980-984 (cited 192 times). 23. Eisinger M, Lee JS, Hefton JM, Darzynkiewicz Z, Chiao KW, deHarven E. (1979) Human epidermal cell cultures: Growth and differentiation in the absence of dermal components or medium supplements. Proc Natl Acad Sci USA 76:5340-5345 (cited 191 times). 24. Darzynkiewicz Z, Bedner E, Gorczyca W, Melamed MR.(1999) Laser scanning cytometry. A new instrumentation with many applications. Exp Cell Res 249: 1-12 (cited 184 times). 25. Del Bino G, Lassota P, Darzynkiewicz Z. (1991) The S-phase cytotoxicity of camptothecin. Exp Cell Res 193:27-35 (cited 184 times). 26. Hotz MA, Gong JP, Traganos F, Darzynkiewicz Z. (1994) Flow cytometric detection of apoptosis. Comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry 15:237-244 (cited 178 times). 27. Darzynkiewicz Z, Traganos F, Sharpless T, Melamed MR. (1975) Thermal denaturation of DNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp Cell Res 90:411-428 (cited 175 times). 28. Hsieh T-C, Juan G, Darzynkiewicz Z, Wu JM. (1999) Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21WAF1/CIP1 and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2. Cancer Res 59: 2596-2601 (cited 173 times). 29. Bruno S, Darzynkiewicz Z. (1992) Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif 25:31-40 (cited 166 times). 30. Darzynkiewicz Z, Traganos F, Staiano-Coico L., Kapuscinski J, Melamed MR. (1982) Interactions of rhodamine 123 with living cells studied by flow cytometry. Cancer Res 42:799-806 (cited 165 times). 31. Darzynkiewicz Z, Staiano-Coico L, Melamed MR. (1981) Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation. Proc Natl Acad Sci USA 78:2383-2387 (cited 162 times). 32. Traganos F, Ardelt B, Halko NM, Bruno S, Darzynkiewicz Z. (1992) Effect of Genistein, a tyrosine kinase inhibitor, on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 52:6200-6208 (cited 155 times). 33. Kapuscinski J, Darzynkiewicz Z, Traganos F, Melamed MR. (1981) Interactions of a new antitumor agent 1,4-dihydroxy-5-8-bis 2-(hydroxyethyl)amino)ethyl)amino)--9,10-anthracenedione with nucleic acids. Biochem Pharmacol 30:231-240 (cited 155 times). 34. Li X, Darzynkiewicz Z. (1995) Labeling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation. Cell Proliferation 28: 571-579 (cited 145 times). 35. Bedner E, Li X, Gorczyca W, Melamed MR, Darzynkiewicz Z. (1999) Analysis of apoptosis by laser scanning cytometry. Cytometry 35: 181-195 (cited 144 times). 36. Del Bino G, Darzynkiewicz Z. (1991) Camptothecin, teniposide or m-AMSA but not mitoxantrone or doxorubicin induce degradation of nuclear DNA in S-phase of HL-60 cells. Cancer Res 51:1165-1169 (cited 143 times). 37. Sharpless T, Traganos F, Darzynkiewicz Z, Melamed MR. (1975) Flow cytofluorometry: Discrimination between single cells and cell aggregates by direct size measurements. Acta Cytol 19:577-581 (cited 141 times). 38. Darzynkiewicz Z, Evenson DP, Staiano-Coico L, Sharpless T, Melamed MR. (1979) Correlation between cell cycle duration and RNA content. J Cell Physiol 100:425-438 (cited 135 times). 39. Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spaminato G, Darzynkiewicz Z, Calabretta B. (1995) Overexpression of DR-nm23, a protein encoded by a member of nm23 family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc Natl Acad Sci USA 92: 7435-7439 (cited 128 times). 40. Darzynkiewicz Z, Gong JP, Juan G, Ardelt B, Traganos, F. (1996) Cytometry of cyclin proteins. Cytometry 25:1-13, 1996 (cited 127 times). 41. Darzynkiewicz Z, Evenson DP, Staiano-Coico L, Sharpless T, Melamed MR. (1979) Relationship between RNA content and progression of lymphocytes through the S phase of the cell cycle. Proc Natl Acad Sci USA 76:358-362 (cited 127 times). 42. Crissman HA, Darzynkiewicz Z, Tobey RA, Steinkamp JA. (1985) Correlated measurements of DNA, RNA and protein content in individual cells by flow cytometry. Science 228:1321-1324 (cited 125 times). 43. Evenson D, Darzynkiewicz Z, Jest L, Janca F, Ballachey B. (1986) Changes in accessibility of DNA in situ to various fluorochromes during spermatogenesis. Cytometry 7:45-53 (cited 125 times). 44. Evenson DP, Darzynkiewicz Z, Melamed MR. (1982) Simultaneous measurement by flow cytometry of sperm cell viability and mitochondrial membrane potential related to cell motility. J Histochem Cytochem 30:279-280 (cited 120 times). 45. Darzynkiewicz Z, Crissman HA, Traganos F, Steinkamp J. (1982) Cell heterogeneity during the cell cycle. J. Cell Physiol 112:465-474 (cited 119 times). 46. Traganos F, Evenson DP, Staiano-Coico L, Darzynkiewicz Z, Melamed MR. (1980) The action of dihydroxyanthraquinone on cell cycle progression and survival of a variety of cultured mammalian cells. Cancer Res 40:671-681 (cited 118 times). 47. Li X, Traganos F, Melamed MR, Darzynkiewicz Z. (1995) Single step procedure for DNA strand-breaks labeling. Detection of apoptosis and DNA replication. Cytometry 20: 172-180 (cited 117 times). 48. Bruno S, Ardelt B, Skierski JS, Traganos F, Darzynkiewicz Z. (1992) Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Res 52:470-473 (cited 116 times) 49. Moran R, Darzynkiewicz Z, Staiano-Coico L,Melamed MR. (1985) Detection of BrdUrd incorporation by monoclonal antibodies: Role of the DNA denaturation step. J Histochem Cytochem 33: 821-827 (cited 112 times). 50. Darzynkiewicz Z. (1995) Apoptosis in antitumor strategies: Modulation of cell cycle or differentiation. J Cell Biochem 58:51-159 (cited 109 times). 51. Darzynkiewicz Z, Traganos F, Sharpless T, Melamed MR. (1977) Cell cycle related changes in nuclear chromatin of stimulated lymphocytes as measured by flow cytometry. Cancer Res 37:4635-4640 (cited 108 times). 52. Darzynkiewicz Z, Carter SP, Mikulski SM, Shogen K. (1988) Cytostatic and cytotoxic effects of Pannon, a novel anticancer agent. Cell Tissue Kinet 21:169-182 (cited 108 times). 53. Darzynkiewicz Z. (1979) Acridine orange as a molecular probe in studies of nucleic acids in situ. In: Flow Cytometry and Sorting. Melamed MR, Mendelsohn M & Mullaney P. (eds.), John Wiley and Sons, New York, pp. 285-316 (cited 107 times). 54. Juan G, Traganos F, James WM, Ray JM, Roberge M, Sauve DM, Anderson H, Darzynkiewicz Z. (1998) Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis. Cytometry 32: 71-77 (cited 107 times). 55. Bedner E, Smolewski P, Amstad P, Darzynkiewicz Z. (2000) Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp Cell Res 259: 308-313 (cited 104 times). 56. Del Bino G, Skierski JS, Darzynkiewicz Z. (1990) Diverse effects of camptothecin, an inhibitor of topoisomerase I on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells. Cancer Res 50: 5746-5750 (cited 104 times). 57. Melamed MR, Enker WE, Janov AJ, Kessler G, Darzynkiewicz Z. (1986) Flow cytometry of colorectal carcinoma with three years follow-up. Dis Col Rec 29:184-186 (cited 104 times). 58. Bruno S, Del Bino G, Lassota P, Giaretti W, Darzynkiewicz Z. (1992) Inhibitors of proteases prevent endonucleolysis accompanying apoptotic cell death. Leukemia 6:1113-1120 (cited 101 times). 59. Collste LG, Devonec M, Darzynkiewicz Z, Traganos F, Sharpless TK, Whitmore WF, Jr, Melamed MR. (1980) Bladder cancer diagnosis by flow cytometry. Correlation between cell samples from biopsy and bladder irrigation fluid. Cancer 45: 2389-2394 (cited 101 times). 60. Olszewski W, Darzynkiewicz Z, Rosen P, Schwartz MK, Melamed MR. (1981) Flow cytometry of breast carcinoma. II. Relation of tumor cell cycle distribution to histology and estrogen receptor. Cancer 48:985-988 (cited 100 times). 61. Gong JP, Ardelt B, Traganos F, Darzynkiewicz Z. (1994) Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. Cancer Res 54:4285-4288 (cited 99 times) 62. Bruno S, Lassota P, Giaretti W, Darzynkiewicz Z. (1992) Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases. Oncol Res 4:29-35 (cited 96 times). 63. Darzynkiewicz Z, Traganos F, Andreeff M, Sharpless TK, Melamed MR. (1979) Different sensitivity of chromatin to acid denaturation in quiescent and cycling cells as revealed by flow cytometry. J Histochem Cytochem 27:478-485 (cited 94 times). 64. Blagosklonny MV, Robey R, Sackett DL, Du L, Traganos F, Darzynkiewicz Z, Fojo T, Bates SE. (2002) Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. Mol Cancer Ther 1: 937-941 (cited 95 times). 65. Kapuscinski J, Darzynkiewicz Z, Melamed MR. (1982) Luminescence of the solid complexes of acridine orange with RNA. Cytometry 2:201-211 (cited 94 times). 66. Balazs EA, Darzynkiewicz Z. (1973) The effect of hyaluronic acid on fibroblasts, mononuclear phagocytes and lymphocytes. In: Biology of the Fibroblast, Papers of the Symposium held in Turku, Finland, 1972; Kulonen, E., and Pikkarainen, J., (Eds.), Academic Press, London, pp. 237-252 (cited 96 times). 67. Devonec M, Darzynkiewicz Z, Kostyrka-Claps ML, Collste L, Whitmore WF, Melamed MR. (1992) Flow cytometry of low stage bladder tumors: Correlation with cytologic and cytoscopic diagnosis. Cancer 49:109-118 (cited 91 times). 68. Del Bino G, Skierski J, Darzynkiewicz Z. (1991) The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp Cell Res 195:485-491 (cited 92 times). 69. Wang ZQ, Dudhane A, Orlikowsky T, Clarke K, Li X, Darzynkiewicz Z. Hoffman, M.K. (1994) CD4 engagement in vivo induces apoptosis in T cells. Eur J Immunol 24: 1549-1552 (cited 90 times). 70. Hotz MA, Traganos F, Darzynkiewicz Z. (1992) Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation. Exp Cell Res 201:184-191 (cited 88 times). 71. Del Bino G, Bruno S, Yi PN, Darzynkiewicz Z. (1992) Apoptotic cell death triggered by camptothecin or teniposide: The cell cycle specificity and effects of ionizing radiation. Cell Proliferation 25:537-548 (cited 85 times). 72. Darzynkiewicz Z, Kapuscinski J. (1990) Acridine orange, a versatile probe of nucleic acids and other cell constituents. In: Flow Cytometry and Sorting. Melamed MR, Mendelsohn M & Lindmo T, (eds.), Alan R. Liss, Inc., New York. pp. 291-314 (cited 84 times). 73. Kajstura J, Zhang X, Reiss K, Szoke E, Li P, Lagrasta C, Cheng W, Darzynkiewicz Z, Olivetti G, Anversa P. (1994) Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing induced cardiomyopathy in rats. Circ Res 74: 383-400 (cited 84 times). 74. Kapuscinski J, Darzynkiewicz Z. (1986) Relationship between the pharmacological activity of antitumor drugs Ametantrone and Mitoxantrone (Novantrone) and their ability to condense nucleic acids. Proc Natl Acad Sci USA 83: 6302-6306 (cited 83 times). 75. Hsieh T-C, Burfeind P, Laud K, Backer JM, Traganos F, Darzynkiewicz Z, Wu JM. (1999) Cell cycle effects and control of gene expression by resveratrol in breast carcinoma cell lines with different metastatic potential. Int J Oncol 15: 245-252 (cited 84 times) 76. Gong JP, Traganos F, Darzynkiewicz Z. (1995) Growth imbalance and altered expression of cyclins B1, A. E and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication. Cell Growth & Differentiation 6: 1485-1493 (cited 85 times) 77. Gong JP, Li X, Darzynkiewicz Z. (1993) Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J Cell Physiol 157: 263-270 (cited 84 times). 78. Staiano-Coico L, Darzynkiewicz Z, Melamed MR, Weksler M. (1984) Immunological studies of aging. Impaired proliferation of T lymphocytes in elderly humans by flow cytometry. J Immunol 132:1788-1792 (cited 81 times). 79. Li X, Gong J, Feldman E, Seiter K, Traganos F, Darzynkiewicz Z. (1994) Apoptotic cell death during treatment of leukemias. Leukemia & Lymphoma 13: Suppl 1, 65-70 (cited 81 times). 80. Traganos F, Kapuscinski J, Darzynkiewicz Z. (1991) Caffeine modulates the effects of DNA intercalating drugs in vitro: A flow cytometric and spectrophotometric analysis of caffeine interaction with Novantrone, doxorubicin, ellipticine and the doxorubicin analog, AD198. Cancer Res 51:3682-3689 (cited 81 times) 81. Darzynkiewicz Z. (1990) Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange. Methods Cell Biol 33: 285-298 (cited 81 times). 82. Gorczyca W, Tuziak T, Kram A, Melamed MR, Darzynkiewicz Z. (1994) Detection of apoptosis in fine-needle aspiration biopsies by in situ end-labeling of fragmented DNA. Cytometry 15: 169-175 (cited 79 times). 83. Kapuscinski J, Darzynkiewicz Z. (1985) Interactions of antitumor agents ametantrone and mitoxantrone (novantrone) with double-stranded DNA. Biochem Pharmacol 34:4203-4213 (cited 77 times). 84. Li X, Melamed MR, Darzynkiewicz Z. (1996) Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color. Exp Cell Res 222: 28-37 (cited 76 times) 85. Darzynkiewicz Z, Gledhill BL, Ringertz NR. (1969) Changes in deoxyribo-nucleoprotein during spermiogenesis in the bull. 3H-actinomycin D binding. Exp Cell Res 58: 435-438 (cited 76 times). 86. Darzynkiewicz Z, Traganos F, Xue SB, Melamed MR. (1981) Effect of n-butyrate on cell cycle progression and in situ chromatin structure of L1210 cells. Exp Cell Res 136:279-293 (cited 73 times) 87. Ringertz NR, Darzynkiewicz Z, Bolund L. (1969) Actinomycin D binding properties of stimulated human lymphocytes. Exp Cell Res 56:411-417 (cited 69 times) 88. Darzynkiewicz Z, Balazs EA. (1971) Effect of connective tissue intercellular matrix on lymphocyte stimulation. I. Suppression of lymphocyte stimulation by hyaluronic acid. Exp Cell Res 66:113-123 (cited 69 times). 89. Staiano-Coico L, Darzynkiewicz Z, Hefton JM, Dutkowski R, Darlington GJ, Weksler M. (1983) Increased sensitivity of lymphocytes from old humans to cell cycle arrest and chromosomal damage induced by 3H-TdR. Science 219:1335-1337 (cited 69 times) 90. Smolewski P, Bedner E, Du L, Hsieh TC, Wu JM, Phelps DJ, Darzynkiewicz Z. (2001) Detection of caspases activation by fluorochrome-labeled inhibitors: multiparameter analysis by laser scanning cytometry, Cytometry, 44: 73-82 (cited 68 times). 91. Zhang JC, Claffey K, Sakthivel R, Darzynkiewicz Z, Shaw DE, Leal J, Wang YC, Lu FM, MacCrae KR. (2000) Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity with domain 5. FASEB J 14: 2589-2600 (cited 67 times) 92. Huang X, Okafuji M, Traganos F, Luther E, Holden E, Darzynkiewicz Z. (2004) Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by DNA crosslinking agent cisplatin. Cytometry A, 58A: 99-110 (cited 66 times) 93. Darzynkiewicz Z., Bedner, E., Smolewski, P. (2001) Flow cytometry in analysis of cell cycle and apoptosis. Semin Hematol 38: 179-193 (cited 65 times) 94. Darzynkiewicz Z, Traganos F. Measurement of apoptosis. (1998) In: Advances in Biochemical Engineering/Biotechnology. Apoptosis. M. Al-Rubeai (Ed). pp 33-73 (cited 63 times) 95. Wang Q, Liu TY, Fang YQ, Xie SQ, Huang X, Mahmood R, Ramaswamy G, Sakamoto KM, Darzynkiewicz Z, Xu M, Dai W. (2004) BUBR1 deficiency results in abnormal megakaryopoiesis. Blood 103: 1278-85 (cited 62 times) 96. Halicka HD, Bedner E, Darzynkiewicz Z. (2000) Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res, 260:248-255 (cited 62 times). 97. Darzynkiewicz Z, Bolund L, Ringertz NR. (1969) Actinomycin D binding of normal and phytohemagglutinin stimulated lymphocytes. Exp Cell Res 55:120-126 (cited 61 times) 98. Pozarowski P, Huang X, Halicka DH, Lee B, Johnson G, Darzynkiewicz Z. (2003) Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells. A caution in data interpretation. Cytometry A, 55A: 50-60 (cited 60 times). 99. Juan, G., Ardelt, B., Mikulski, S.M., Shogen, K,M Ardelt, W., Mittelman, A., Darzynkiewicz, Z. (1998) G1 arrest of U-937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation. Leukemia, 12:1241-1248 (cited 60 times) 100. Del Bino G, Darzynkiewicz Z, Degraef C, Mosselmans R, Galand P. (1999) Comparison of methods based on annexin V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells. Cell Prolif 32: 25-37 (cited 60 times) 101. Abraham NG, Kushida T, McClung J, Weiss M, Quan S, Lafaro R, Darzynkiewicz Z, Wolin M. (2003) Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res., 93:507-514 (cited 59 times). 102. Darzynkiewicz Z, Traganos F, Xue S, Staiano-Coico L, Melamed MR. (1981) Rapid analysis of drug effects on the cell cycle. Cytometry 1:279-286 (cited 58 times) 103. Darzynkiewicz Z, Traganos F, Sharpless T, Melamed MR. (1977) Recognition of cells in mitosis by flow cytofluorometry. J. Histochem Cytochem 25:875-880 (cited 58 times) 104. Li, X., Darzynkiewicz, Z. (2000) Cleavage of poly(ADP-ribose)polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res 255: 125-132 (cited 57 times). 105. Seiter K, Feldman E J, Halicka D, Traganos F, Darzynkiewicz Z, Lake D, Ahmed T. (1997) Phase I clinical and laboratory evaluation of topotecan and cytoarabine in patients with acute leukemia. J Clin Oncol 15: 44-55 (cited 57 times) 106. Capasso JM, Bruno S, Cheng W, Li P, Rodgers R, Darzynkiewicz Z, Anversa P. (1993) Ventricular loading is coupled with DNA synthesis in adult cardiac myocytes after acute and chronic myocardial infarction in rats. Circulation Res 71: 1379-1389 (cited 56 times) 107. Deptala, A., Bedner, E., Gorczyca, W., and Darzynkiewicz, Z. (1998) Simple assay of activation of nuclear factor kappa B (NF-?B) by laser scanning cytometry (LSC). Cytometry, 33: 376-382 (cited 55 times) 108. Rivas CI, Wisniewski D, Strife A, Perez A, Lambek C, Bruno S, Darzynkiewicz Z, Clarkson B. (1992) Constitutive expression of p53 protein in enriched normal human marrow blast cell populations. Blood 79:1982-1986 (cited 54 times) 109. Gong JP, Li X, Traganos F, Darzynkiewicz Z. (1994) Expression of G1 and G2 cyclins measured in individual cells by multiparameter flow cytometry; a new tool in the analysis of the cell cycle. Cell Prolif 27: 357-371 (cited 52 times) 110. Darzynkiewicz Z, Bedner E, Traganos F, Murakami T. (1998) Critical aspects in analysis of apoptosis and necrosis. Human Cell 11:3-12 (cited 53 times). 111. Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W. (2002) Cell cycle arrest and apoptosis induced by human polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol. Cell Biol. 22: 3450-59 (cited 51 times) 112. Ronai Z, Tillotson JK, Traganos F, Darzynkiewicz Z, Conaway C, Upadhyaya P, El-Bayoumy K.(1995) Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int J Cancer 63: 428-434 (cited 52 times). 113. Huang X, Halicka HD, Traganos F, Tanaka T, Kurose A, Darzynkiewicz Z. (2005) Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis. Cell Prolif 38: 223-243 (cited 51 times) 114. Del Bino G, Li X, Traganos F, Darzynkiewicz Z. (1994) Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia 6: 281-288 (cited 50 times) 115. Darzynkiewicz Z., Barnard EA. (1967) Specific proteases of the rat mast cell. Nature 213:1198-1202 (cited 50 times) (Hirsch's citation h-index = 81)
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Contact: Zbigniew Darzynkiewicz |
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