Zbigniew Darzynkiewicz, M.D., Ph.D.

About Zbigniew

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Cytometry 4th Edition

Preface Table of Contents

Name:		Zbigniew Darzynkiewicz
DOB:		May 12, 1936
POB:		Dzisna, Poland
Nationality:		USA (Naturalized, 1976)

EDUCATION:

1945-1949		Primary School, Dzierzoniow, Poland
1949-1953		High School (Gymnasium and Lyceum) Skarzysko, Poland; (graduated with the highest honors)
1953-1960		University (School of Medicine), Warsaw, Poland. Received M.D. degree with the highest honors, 1960

SCIENTIFIC DEGREE:

The degree Doctor of Medical Sciences (equivalent of Ph.D.) awarded by the Faculty Council of the School of Medicine in Warsaw, Poland, 1966, on the basis of the thesis entitled: "Studies of the Mechanism of Teratogenic Action of Insulin on Chicken Embryo", and after passing examinations in Philosophy, Cell Biology, Biochemistry and History of Medicine.

POSITIONS AND APPOINTMENTS:

1960-61		Resident in Surgery, IVth City Hospital, Warsaw
1962-65		Predoctoral Fellow, Department of Histology, School of Medicine, Warsaw
5/65-7/66		Research Associate, Department of Pharmacology, Molecular Enzymology Unit, SUNY at Buffalo, N.Y.
7/66-9/68		Assistant Professor, Department of Histology, School of Medicine, Warsaw
9/68-12/69		Visiting Scientist, Laboratory of Cell Research, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
12/69-2/74		Staff Scientist, Department of Connective Tissue Research, Boston Biomedical Research Institute, Boston, Mass.
3/74-12/75		Research Associate, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
1/76-3/78		Assistant Professor, Cornell University, Graduate School of Medical Sciences, New York, N.Y.
6/78-6/88		Associate Member, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
6/78-6/88		Associate Professor of Cell Biology and Biochemistry, Cornell University, Graduate School of Medical Sciences, New York, N.Y.
1/86-9/90		Head, Laboratory of Experimental Cell Research, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
7/88-9/90		Member, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
7/88-9/90		Professor of Cell Biology and Genetics, Cornell University, Graduate School of Medical Sciences, New York, N.Y.
6/89-9/90		Director, Flow Cytometry Core Facility Network, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
10/90-pres.		Professor of Medicine, New York Medical College, Valhalla, N.Y.
10/90-pres.		Director, Brander Cancer Research Institute (formerly: Cancer Research Institute), New York Medical College, Valhalla, N.Y.
11/91-pres.		Professor of Microbiology and Immunology, New York Medical College, Valhalla, N.Y.
11/92-pres.		Professor of Pathology, New York Medical College, Valhalla, N.Y.

AWARDS, HONORS, GRANTS:

1955-60		Student Scholarship, the award from the School of Medicine (Warsaw) for excellence in academic work and engaging in research (stipend to cover tuition and living expenses)
1962-65		Doctoral Fellowship awarded by the Polish Academy of Sciences, Warsaw, Poland
1970-72		Scholarship Grant (PS-57) awarded by the American Cancer Society, Inc., NewYork, N.Y.
1972		Included in: "American Men and Women of Science", (Marquis Publ.)
1973-75		Research Grant from Charles A. King Trust, Boston, Mass. (Principal Investigator)
1975-89		Research Grant from NCI (CA14134) "Automation of Urinary Cytology". Co-Investigator. (M.R. Melamed, Principal Investigator)
1978-87.		Research Grant from NCI (RO1-CA23296) "Effects of New Antitumor Drugs on the Cell Cycle" (Principal Investigator); renewed in: 1981, 1984 and 1987.
1978		"Gold Millenium of Poland Medal", awarded by the Polish-American Medical Society, USA, in recognition of research accomplishments. Award shared with Drs. Andrew Schally, Ludwik Gross, Hilary Koprowski and Zbigniew Brzezinski.
1980-pres.		Research Grant from NCI (RO1-CA28 704) "Probes for Flow Cytometry" (Principal Investigator); renewed in: 1983, 1987, 1990, 1995 and 1999.
1983-pres.		Included in: "Who's Who in America", "Who's Who in Technology", "Who's is Who in Cancer Research", "Who's Who in Medicine and Healthcare" (Marquis Publ.)
1985-86		Vice-President and Program Chairman, The Cell Kinetics Society
1986-87		President, The Cell Kinetics Society
1986-1999		Member, Advisory Board, The Alfred Jurzykowski Foundation, New York, N.Y.
1987-92.		NASA consultant on flow cytometry in the Space Station
1987		MERIT Award Research Grant from NCI (R37-CA23296) "Effects of New Anticancer Drugs on the Cell Cycle" (Principal Investigator)
1990		Grant-Contract from NASA to develop the "Liquidless" staining of cells applicable to conditions of the Space Station (Principal Investigator)
1990-pres.		Yearly Research Fund Awards provided by the "This Close" Foundation for Cancer Research, Inc., New Haven, CT.
1992-94		President of the International Society for Analytical Cytology (ISAC) and Program Chairman of the XVIIth ISAC Congress (Lake Placid, 1994)
1994		Honorary Editor, Cytometry Research (Japan)
1994-pres.		Yearly Research Grants provided by the Robert A. Welke Foundation for Cancer Research, Fairfield, CT.
1995		Honorary member, Cytometry Society of Japan
1996		Member (Foreign), Polish Academy of Sciences (PAU), Cracow, Poland
1996		Honorary member of the Polish Cytometry Society
1997-98		Research Grant from Alfacell Corp., Bloomfield, N.J. providing funds to study antitumor activity of ONCONASE (Principal Investigator)
1997		Honorary member of the Iberian Cytometry Society
1997-00		Research Grant from Eli Lilly Pharmaceutical Co., Indianapolis, IN providing funds to study mechanism of action of new antitumor drugs (Principal Investigator).
2000		Medal of Honor awarded by the Polish Society of Hematology and Transfusion Medicine. Also, honorary membership in this Society.
2001		Research grant provided by the Matrix Charitable Institute, N.J. to study effects of intercellular matrix components on cells.
2001		Thomson ISI Essential Science IndicatorsTM – # 20 on the list of 25 world top ranked authors on topic of “Apoptosis” based on number of papers and citations 1991-2001
2002		Distinguished Service Award, International Society for Analytical Cytology
2003		"This Close" for Cancer Research Foundation Special Award
2004		The Dean's Distinguished Research Award, NYMC
2004		"Best Paper Published in CYTOMETRY in 2003" Award
2006		"The Fulwyler Award for Innovative Excellence", bestowed by the International Society for Analytical Cytology (ISAC).

EDITORIAL ACTIVITY:

North American Editor:

CELL PROLIFERATION (Formerly: CELL AND TISSUE KINETICS) (1988-present)

CYTOMETRY A (2007-present)

Editor or Co-Editor:

	CYTOMETRY (Reviews) Journal of the Society for Analytical Cytology (1993-1999)
	EXPERIMENTAL CELL RESEARCH (1996 - present)
	CURRENT PROTOCOLS IN CYTOMETRY (1996 - present)
	FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (1998 - present)
	METHODS IN CELL BIOLOGY (Ac. Press), Volumes 33, 41, 42, 63, 64, and 75, Editor

Associate Editor, Editorial Board Member:

	CYTOMETRY, The Journal of the Society for Analytical Cytology (1980-present)
	JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY (1983-1993)
	INTERNATIONAL JOURNAL OF ONCOLOGY (1992-present)
	CANCER THERAPY (www.cancer-therapy.org) (2003-present)
	LEUKEMIA RESEARCH (1984-1989)
	LEUKEMIA (1988-2004)
	CELL AND TISSUE KINETICS (1987-1988)
	CELL BIOLOGY AND TOXICOLOGY (1993-present)
	POLISH JOURNAL OF IMMUNOLOGY (1995-1996)
	CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (1996 - present)
	CYTOMETRY RESEARCH (Japan). Honorary Editor (1994 - present)
	EXPERIMENTAL ONCOLOGY (1996-present)
	"inScight" (Daily Science News Service on the Internet, Academic Press) (1998-present)
	HUMAN CELL (Japan) (2002-present)
	CELL CYCLE (2002-present)
	CANCER THERAPY (2003-present)
	PREVENTIVE MEDICINE (2003-present)
	CENTRAL-EUROPERAN J. MEDICINE (2005-present)
	THE OPEN ENZYME INHIBITION JOURNAL (2008-present)

MEMBER OF THE REVIEW COMMITTEES, ADVISORY BOARDS OR STUDY SECTIONS, AND/OR CONSULTANT TO (DURING PAST 20 YEARS):

	National Cancer Institute (NIH) Special Study Sections and the Cell Physiology Study Section
	American Cancer Society
	National Science Foundation
	U.S. Department of Energy
	International Advisory Panel N.A.S., Chinese University Development Project
	NASA (Houston, TX)
	Medical Research Council of Canada, Toronto, CA
	Wilhelmina Foundation, The Netherlands
	Alfacell Corporation, Bloomfield, N.J., Advisory Board Member.
	Tobacco-Related Diseases Research Program, University of California, San Francisco, CA.
	Alfred Jurzykowski Foundation Advisory Board Member, New York, N.Y.
	The Israel Science Foundation of the Israel Academy of Sciences and Humanities, Jerusalem, Israel
	National Cancer Institute of Canada
	Eli Lilly Pharmaceutical Co, Indianapolis, IN
	CompuCyte Corp., Cambridge, MA
	PharMingen/Becton Dickinson Corp., San Diego, CA
	Phoenix Flow Systems, Inc., San Diego, CA
	Marsden Fund, The Royal Society of New Zealand, Wellington, New Zealand
	Wyeth-Ayerst Pharmaceutical Co., Princeton, N.J.
	Intergen Co., Purchase, NY
	PharmaSeq Corp., Princeton, NJ. Advisory Board Member
	Agouron Pharmaceuticals, Inc;/Div of Pfizer Corp., San Diego, CA
	United States - Israel Bi-national Foundation, Jerusalem, Israel
	American Health Foundation/Institute for Cancer Prevention, Valhalla, NY
	Mathematical Biosciences Institute, Ohio State U. Columbus, OH
	Aventis Pharnmaceutical Co., Paris, France

MEMBERSHIP IN SCIENTIFIC ORGANIZATIONS:

	American Association for Cancer Research
	American Association for Advancement of Science
	International Society for Analytical Cytology (Charter Member; Hold functions: President of the Society, Councilor, Nominating Committee Chairman, Program Committee Chairman)
	The Cell Kinetics Society (Hold functions: Vice-President, Program Committee Chairman, President of the Society, and Journal Liaison)
	International Cell Cycle Society
	N.Y. Academy of Sciences
	European Study Group for Cell Proliferation (ESGCP; Honorary Member)
	Polish Cytometry Society (Honorary Member)
	Polish Society of Hematology and Transfusion Medicine (Honorary Member)
	Cytometry Society of Japan (Honorary Member)
	Iberian Cytometry Society (Honorary Member)
	Polish Institute of Arts and Sciences in America (New York)
	The Jozef Pilsudzki Institute of History in New York (Member of the Board, 1994-6)

INVITED FACULTY MEMBER AND/OR COURSES/MEETINGS ORGANIZER/CO-ORGANIZER (SINCE 1980):

	3rd and 4th National Annual Course in Flow Cytometry. University of Rochester, N.Y. (1981,1982)
	First ORTHO Conference on Methods in Flow Cytometry. Boston, Mass. (1982)
	National Flow Cytometry Resource. Annual Course in Flow Cytometry, Los Alamos Natl. Laboratory, Los Alamos, N.M., 1983, 1985, 1987, 1989, 1995, 1997, 1999, 2003; Albuquerque, N.M.,1991;
	National Flow Cytometry Resource. Annual Course in Cytometry, Philadelphia, PA.,1984, 1986, 1988
	"Flow Cytometers and Sorters Course." University of Wisconsin, Madison,WI., 1983
	Advanced Methods Course in Flow Cytometry and Sorting. University of Rochester, N.Y. 1983
	Visiting Professor. Beijing Normal University, Beijing, China, Oct 1 - Nov. 16, 1984
	International Flow Cytometry Course. Villejuif Cancer Center, Paris, France, 1984, 1985,1988, 1990,
	10th Annual Meeting of Cell Kinetics Society. Meeting Organizer and Chairman of the Program Committee. Santa Fe, NM, March 18-21, 1986.
	Flow Cytometry and Sorting Course. Waksman Institute of Microbiology, Rutgers University, Piscataway, N.J. October, 1987, November, 1988
	Visiting Professor. Institute of Basic Medical Sciences and Beijing Normal University, Beijing, China, October, 17-26, 1987
	Advanced Course on Flow Cytometry. Loyola University, Chicago, Ill., October, 1988
	BECTON-DICKINSON Workshop on Flow Cytometry. San Francisco, California, December, 1989
	Clinical and Basic Flow Cytometry Course. Cornell University Medical Center, New York, N.Y. May, 1989
	National Annual Course in Flow Cytometry. Bowdouin College, Brunswick, Maine, May, 1990, May, 1996, May 1998, June 2000; June 2004.
	National Annual Clinical Flow Cytometry Course, Dartmouth U., Hanover, NH, 1999; 2001; 2002; 2003; Pittsburgh, PA, 2004.
	15th Congress of the International Society of Analytical Cytology (ISAC). August 1991,Tutorial course on cytochemistry,
	NATO Advanced Study Institutes International Course in Flow Cytometry. Villejuif France, 1992 and 1995
	International Workshop on Flow and Image Cytometry. Porto, Portugal, 1991, 1993.
	17th Congress of International Society for Analytical Cytology (ISAC), Congress Organizer and Chairmen of the Program Committee, > 1,000 persons in attendance, Lake Placid, NY, October 16-21, 1994. Also giving tutorial course on apoptosis.
	18th Congress of International Society for Analytical Cytology (ISAC), Rimini, Italy, April 1996 Tutorial course on apoptosis
	European Summer School on Clinical Applications of Flow Cytometry, Antwerp, Belgium, July 1-3, 1996; July 2-5; 1997; July 2-4 1998.
	26th Congress of the International Society of Hematology (ISH). Singapore, August 1996. Tutorial course on apoptosis.
	29th Congress of International Society for Analytical Cytology (ISAC), Colorado Springs, CO. February 28- Mar 4, 1998. Tutorial course on apoptosis
	International Workshop on Cytometry Gdansk, Poland, October 19-20, 1998.
	The XIth Conference on DNA Topoisomerases in Therapy (Conference co-organizer; Program co-chair) New York, N.Y, October 6 -10, 2001.
	International Symposium on Apoptosis (Symposium co-organizer; Program co-chair), Nagasaki, Japan, November 17, 2002.
	23rd Congress of International Society for Analytical Cytology (ISAC), Quebec City, Canada. May 19-25, 2006. Tutorial course: Cell cycle and Apoptosis.
	24th Congress of International Society for Advancement of Cytometry, Budapest, Hungary, Mat16-21, 2006. Tutorial course: Assessment of DNA damage by Cytometry.

PUBLICATIONS:

As of May 2008 Zbigniew Darzynkiewicz is an author or co-author of over 535 peer-reviewed publications, 100 book chapters and an author or editor of 12 books. His papers were cited in the biomedical literature over 22,000 times. His “h-index” (Hirsh’s) citation ranking is #78. Since 1980, by invitation, he presented over 320 lectures and seminars on national and international congresses, symposia, and in research institutions.

INVENTIONS:

(1)	Flow Cytometry-Fluorescence Measurements for Characterizing Sperm. U.S. Patent No. 4,559,309; Issued Dec. 17, 1985
(2)	Method for Separating and Analyzing Nucleic Acids. U.S. Patent No. 4,801,550; Issued Jan. 31, 1989
(3)	Detection of Halogenated Precursors Incorporation by Selective Photolysis of Halogenate- Substituted Bases U.S. Patent No. 5,747,258, Issued May 5, 1998
(4)	Methods for Labeling DNA Ends with Halogenated Nucleotides and Detecting the Same with Antibodies , U.S. Patent No. 5,912,126, Issued June 15, 1999
(5)	Physical Separation of Nucleic Acids by Antibodies to Halogenated Nucleotides US patent No. 6,417,343, issued July 9, 2002.
(6)	Flow cytometric methods for the concurrent detection of discrete functional conformations of pB in single cells. US patent No. 6,821740, issued November 23, 2004.
(7)	Detection of protein conformation in single cells. US patent 7,070,943, issued July 4, 2006.

LANGUAGES:

English, Polish, Russian (passive)

OFFICE ADDRESS:

Brander Cancer Research Institute New York Medical College Valhalla, NY. 10595 Telephone: (914) 594-3780 Telefax: (914) 594-3790 e-mail: darzynk@nymc.edu

MILITARY STATUS:

Never served in the U.S. military forces (naturalized in 1976)

MARITAL STATUS:

Married, spouse's name: Elizabeth T. Darzynkiewicz (M.D., Radiologist)

CHILDREN:

Richard B. Darzynkiewicz,

	M.S. in Chemistry, University of Rochester (NY).
	Graduate studies (Masters) in Rice University, Houston, TX.
	Webmaster, United Space Alliance, Houston, TX.

Robert J. Darzynkiewicz,

	M.S. in Molecular Biology, U.C. at Berkeley.
	Graduated (M.D.) at N.Y. Medical College, Valhalla, NY.
	Resident in Emergency Medicine at Albert Einstein/ Jacobi Hospital, NYC.
	Attending Physician at EM, Reno Hosp., Reno NE
	U.S. National Junior Swimming champion (1,500 m freestyle;1988 and 1989).
	Gold medalist at the 1993 World University Games (1,500 m freestyle swimming).
	U.S. (junior division) record holder 1,500 m swimming (since 1982).

HOBBIES:

Swimming, skiing, windsurfing, sailing, photography

Contact: Zbigniew Darzynkiewicz